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In solid tumors such as those in breast
2020-12-10
In solid tumors, such as those in breast and pancreatic cancer, infiltrating CD68+ or CD163+ tumor-associated macrophages (TAMs) correlate with poor outcome (DeNardo et al., 2011, Kurahara et al., 2011, Shabo et al., 2008). The tumor-promoting function of TAMs is based on their capacity to secrete p
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NHS-LC-Biotin The objective of the present
2020-12-10
The objective of the present study was to investigate the role of the CRF system in the neuroadaptations associated with nicotine dependence. To this aim, the regulation of the gene expression of CRF and its receptors was assessed in NHS-LC-Biotin regions belonging to the reward pathway using a mod
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Several mechanisms are implicated in lipid induced
2020-12-10
Several mechanisms are implicated in lipid-induced insulin resistance in muscle, including oxidative stress (Koves et al., 2008, Zhang et al., 2011, Muoio and Neufer, 2012). Mitochondrion is a major source of ROS production. The oxidation of pyruvate and fatty Carbetocin yielding acetyl-CoA occurs
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br Materials and methods br Results
2020-12-10
Materials and methods Results Discussion In the past decade, GWAS have attempted to identify genetic variants that confer risk for many human diseases, whose inherited components remain unexplained (Manolio et al., 2009). In a few cases risk variants identified by GWAS have paved the way fo
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epacadostat TR provides requirements for qualification of co
2020-12-09
TR-107330 (1996) provides requirements for qualification of commercial PLC. It uses the criteria of NUREG/CR-6421. EPRI TR-104159 (1995) includes experience about dedicating COTS SW for PLC-based digital systems such as DAFAS (Diverse Auxiliary Feedwater Actuation System) and Emergency Diesel Bus Lo
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br Experimental br Declaration of interest
2020-12-09
Experimental Declaration of interest Introduction Material and methods Results and discussion Conclusion By screening the NMR phenylephrine hydrochloride synthesis library an initial hit was found for an inhibitor of the PPI between the α-β subunits of CK2 with an IC50 of 900 μM.
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These data indicate that in the context
2020-12-09
These data indicate that, in the context of the N-terminal 42 amino acids of p53, threonine 18 is a substrate for phosphorylation by CK1 as mediated by prior phosphorylation of serine 15. To determine whether this is a property of full length p53, GST-p53 fusion proteins comprising the full length p
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Two additional hydrogen bonds are formed by the
2020-12-09
Two additional hydrogen-bonds are formed by the -substituted methoxy-group with Ser and Asp. Ser exerts the role of a gate keeper in CK1: Entry of the ATP in the binding-site causes a conformational change into the closed form by Ser, which locks the binding-site and prevents ATP-diffusion out of th
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To our knowledge this study is the first to
2020-12-09
To our knowledge, this study is the first to construct a whole-body transcriptome of D. variabilis. Most of the data currently accessible in NCBI are derived from a midgut EST database consisting of 1679 transcripts (Anderson et al., 2008) and about 20,000 mRNA sequences from the testis-vas deferens
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Although the analysis described above goes far to explain th
2020-12-09
Although the analysis described above goes far to explain the mechanism of proteasome perturbations through CHK1 inhibition, it raises important questions about the mechanism by which WT RAS isoforms promote CHK1 S280 phosphorylation. Previous reports have shown that both the MAPK-RSK and PI3K-AKT
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br Acknowledgements br A subgroup of pediatric solid neoplas
2020-12-09
Acknowledgements A subgroup of pediatric solid neoplasms, collectively referred to as small round cell tumors (SRCTs) of childhood, demonstrates undifferentiated small round cell morphological characteristics. The SRCTs include neuroblastomas, lymphomas, and several bone and soft tissue sarcoma
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A possible explanation for these
2020-12-09
A possible explanation for these observations has been provided by a recent study showing that EWS-FLI-1 increases the Skp2-mediated 26S proteasome degradation, decreasing p27 protein stability and preventing cell senescence [42]. Mechanism of action of EWS-FLI-1 Molecular analysis has revealed
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Although several genomic technologies including the generati
2020-12-09
Although several genomic technologies, including the generation of ERRγ-specific knockout mice, have revealed that ERRγ plays a pivotal role in cellular bioenergetics [1], its involvement in other metabolic pathways has been appreciated only recently. Therefore, we highlight recent findings on the r
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br Methods br Results br Discussion I R induces
2020-12-09
Methods Results Discussion I/R induces oxidative stress and increases the intracellular levels of ROS, resulting in tissue damage [31]. ROS is generated by mitochondrial electron transport chain, nicotinamide L002 dinucleotide phosphate (NADPH) oxidase complex, xanthine oxidase and NOS [32
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The role of ETB clearing receptors has been studied in
2020-12-09
The role of ETB clearing receptors has been studied in detail in endothelial cell–specific ETB knock-out mice. In these animals, clearance of an intravenous mdm2 p53 of labeled ET-1 was reduced significantly compared with wild-type controls. Importantly, functioning ETB were retained on all other c
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