• Protein ubiquitination occurs at the lysine residues and

  2019-11-04

  

  Protein ubiquitination occurs at the lysine residues, and is mediated by the sequential reactions of ubiquitin-activating enzyme (E1), conjugating enzyme (E2), and ligase (E3). The first step in this process comprises the ATP-dependent activation of ubiquitin by E1 to form a ubiquitin–E1 conjugate.

• Introduction Enzymes have higher selectivity specificity and

  2019-11-04

  

  Introduction Enzymes have higher selectivity, specificity and efficiency than chemical catalysts. Due to their properties and their green chemistry, biocatalysts are widely used in food, textile and pharmaceutical industry [1], [2]. A high efficient biocatalyst for industrial applications must be s

• The folate pathway plays an essential role in cell survival

  2019-11-04

  

  The folate pathway plays an essential role in cell survival by generating 5, 10-methylene tetrahydrofolate as a one-carbon donor for the synthesis of deoxythymidine monophosphate (dTMP), purines, methionine and histidine. Disruption of this pathway leads to the critical deficiency of these key molec

• NMR was employed for the determination of un

  2019-11-04

  

  NMR was employed for the determination of un-ligated domain 1 structure of DDR2 receptor. The collagen-binding site on the same was identified by cross saturation experiment and mutagenesis [40]. Birgit leitinger identified the binding site of collagen with DDR2 receptor, which was three spatially a

• An Ubl modification requires several steps that are catalyze

  2019-11-04

  

  An Ubl modification requires several steps that are catalyzed by three enzymes, referred to as E1 (activating enzyme), E2 (conjugation enzyme), and E3 (ligase). The SUMO E1 is a heterodimer of SAE1 and Uba2 (also known as SAE2). In brief, an Ubl is first activated by E1 through ATP hydrolysis and f

• br Conflicts of interest br Acknowledgements This study

  2019-11-04

  

  Conflicts of interest Acknowledgements This study was funded by Kuwait University Research Administration (Project MI03/10). Introduction Epidemiological, experimental and biologic plausibility support a cardioprotective effect of estrogens in women [1]. Indeed, women are protected until t

• Sampling sediments is usually performed with grab corers The

  2019-11-04

  

  Sampling sediments is usually performed with grab corers [16], [29]. The digested sludge analyzed by Ternes et al. [16] was taken directly from the digester and the activated sludge was obtained by Mitomycin C mg of the slurry of STPs [16]. Collected samples are transported under cooled conditions

• As with all meta analysis this

  2019-11-04

  

  As with all meta-analysis, this study certainly has some limitations. First, our results were derived from unadjusted analyses due to lack of raw data, and lack of further adjusted analyses for age, gender and co-morbidity conditions may impact the reliability of our findings [63]. Second, obvious h

• Several studies have demonstrated that Syn specifically asso

  2019-11-04

  

  Several studies have demonstrated that αSyn specifically associates with lipid rafts (Cole et al., 2002), raising the possibility that the perturbation of rafts can affect the aggregation and phosphorylation of αSyn (Fortin et al., 2004). Schneider et al. (2010) described the potential involvement o

• The idea that ASB can drive

  2019-11-04

  

  The idea that ASB11 can drive compartment expansion in the CNS is further supported by in vitro work in human neuronal precursors. Nerve growth factor (NGF)-induced differentiation of PC12 pheochromocytoma BGB324 [11] and RA-induced human pluripotent teratocarcinoma carcinoma (NT2) cells [12] const

• br Materials and methods br Results and discussion br

  2019-11-04

  

  Materials and methods Results and discussion Conflict of interest Acknowledgments This work was supported by grants from National 973 Project (2015CB755700) and the Doctoral Starting up Foundation of Henan University of Science and Technology (13480033). Introduction Progression thro

• ERK and p MAPK signaling

  2019-11-02

  

  ERK and p38 MAPK signaling pathways play critical role in genesis and metastasis of melanoma (Tang et al., 2018). >50% of melanoma 8-Hydroxy-DPAT hydrobromide (Abildgaard and Guldberg, 2015) show abnormal activity of BRAF-RAS-RAF to activate MEK signal that drives the growth-promoting extracellular

• A study profiling chemokine expression in LCLs

  2019-11-02

  

  A study profiling chemokine expression in LCLs revealed high expression levels of CCR6, CCR7, and CCR10 and low expression of CXCR4 and CXCR5 in EBV immortalized cells. Accordingly, LCLs showed a markedly increase in migration in response to the ligands of CCR6 (CCL20), CC7 (CCL21), and CCR10 (CCL28

• br RING dimerization RING type domains

  2019-11-02

  

  RING dimerization RING-type domains are found in many different structural contexts. While many exist as single-chain Anisomycin (Fig. 3A), a notable feature of RING-type E3s is their tendency to form homodimers and heterodimers (Fig. 3C–F). Homodimeric RING-type E3s include cIAP, RNF4, BIRC7 (s

• The activity of chromenones bearing

  2019-11-02

  

  The activity of chromenones bearing heteroaryl groups at the 8-position is summarised in . Replacement of the 8-phenyl substituent of by a thiophen-2-yl group ( and ) did not improve DNA-PK inhibitory activity, although the 4-phenylthiophen-2-yl derivative (), together with the bithiophene analogue

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